The Program
Day 1 - Wednesday 11th June 2025
1:30 – 2:30 pm
2:30 – 3 pm
3 – 4 pm
4 – 4:30 pm
4:30 – 6 pm
7 pm - late
Delegates’ Arrival and Registration
Opening Remarks by the IPSCC 2025 Organising Committee
Keynote Speaker – Samra Turajlic (The Francis Crick Institute, UK)
Tracking cancers in time and space
Coffee Break
PhD Students Talks - Cancer Initiation and Drivers
Baizi Chen (The Francis Crick Institute) - Stabilized MYCT58A bypasses T-Cell Help to fuel Germinal Center B-Cell lymphomagenesis
Louis Roussel (CRUK Manchester Institute) - Developing an isogenic series of CRISPR-edited organoids to determine transformative dependencies of KRAS-mutant alleles
Tracer Yong (Karolinska Institute) - Clonal evolution analysis of paediatric lymphoma reveals a highly diversified cellular status and potential targets for precision medicine
Giulia Beccaceci (Max Delbrück Center) - Helicobacter pylori infection causes gastric mucosal reprogramming into a proinflammatory, fetal-like state
Konstantina Strepi (Netherlands Cancer Institute) - Ex vivo culture platform and novel lobular breast cancer mouse models reveal distinct molecular features between AKT and PIK3CA breast cancers
Lucy Barton (CRUK Manchester Institute) - Chromosome 8Q gains and prostate cancer aggression
Social Night at the Student Union (University of Manchester)
Day 2 - Thursday 12th June 2025
8:30 – 9 am
9 – 10 am
10 - 11 am
11 – 11:30 am
11:30 – 12:30 pm
12:30 – 1:30 pm
1:30 – 3:30 pm
3:45- 5:00 pm
5:00 – 6:00 pm
7 pm – late
Welcome
PhD Students Talks - Cancer Detection
Idris Ola (German Cancer Research Centre) - Colorectal cancer incidence, mortality, and stage-specific trends in European countries during the screening era: results from population-based cancer registries
Martina Bouka (Max Delbrück Center) - Genetically predicted IL-6 and TNF-α and Colorectal cancer specific mortality: A two-sample Mendelian Randomization
Milad Ahmadian (Netherlands Cancer Institute) - An explainable and ensemble feature selection method combining particle swarm optimisation with adaptive LASSO in multicentre MRI radiogenomics
Shahin Roshani (Netherlands Cancer Institute) - Predicting absolute risk of first relapse in classical Hodgkin lymphoma by incorporating contemporary treatment effects
Patients’ Advocates Session
Coffee Break
The EMBO Keynote Lecture - Maria Rescigno (Humanitas University, IT)
The microbiota in cancer progression and treatment
Lunch Break
PhD Students Talks
Novel Cancer Therapeutic Strategies
Dorothy Yang (CRUK City of London) - Developing next-generation armoured hypoxia-sensing CAR-T cells
Kirsten Tinsley (CRUK Manchester Institute) - The role of cell-cell interactions in the survival and dissemination of small cell lung cancer circulating tumour cells
David MacLean (CRUK Scotland Institute) - The KRAS(G12D)-specific inhibitor, MRTX1133, reduces precursor lesion burden and drives tumour regression in an autochthonous model of pancreatic cancer
Rosa Rapuano Lembo (European School of Molecular Medicine) - Generation and characterization of novel human anti-OX-40 monoclonal antibodies for therapy of cancer and infectious diseases
Epigenetic Drivers of Tumours
Jingru Xu (CRUK Manchester Institute) - IRF2BP2/TRIM28/DNMT1 suppresses transposable elements expression to maintain AML survival
Emma Minnee (Netherlands Cancer Institute) - ‘A needle in the haystack’ – Which Androgen Receptor binding site is critically involved in driving castration resistant metastatic prostate cancer?
Cancer Metabolism
Ying Thong Low (The Francis Crick Institute) - Vitamin B2 depletion induces stress and 2HG-dependent metabolic remodelling in cancer cells
Francisco Yanqui-Rivera (German Cancer Research Centre) - NAD precursors in glioblastoma reveals TDO2-driven adaptation and AHR-related vulnerabilities
Careers’ Workshops
First Poster Session
Conference Dinner at the Albert’s Shed
Day 3 - Friday 13th June 2025
9 – 9:30 am
9:30 – 11 am
11 – 11:30 am
11:30 – 12:30 pm
12:30 – 1:30 pm
1:30- 2:30 pm
2:30 – 3:30 pm
3:30 – 4 pm
Welcome
CRUK Manchester Institute Group Leaders Panel
Santiago Zelenay (Cancer Inflammation and Immunity Lab) - The dual role of inflammation in cancer immunity
Amaya Viros (Skin Cancer and Ageing Lab)
Sylvain Delaunay (RNA Dynamics in Cancer) - The RNA modifications dictating cancer progression
Coffee Break
PhD Students Talks - Tumour Microenvironment
Pietro Andrei (The Francis Crick Institute) - The local immune microenvironment drives response to immunotherapy in colorectal cancer
Paula Camargo Romera (Karolinska Institute) - The tumour microenvironment influences long-term tamoxifen treatment response in breast cancer patients
Guido Krähenbühl (Max Delbrück Center) - Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth
Efi Tsouri (Netherlands Cancer Institute) - Crosstalk between senescent cancer cells and the TME reveals myeloid cell centric therapeutic targets in HCC
Lunch
Second Poster Session
PhD Students Talks
Hannah Sheedy (CRUK Manchester Institute) - Development of a single-cell methylation workflow to understand the biology of circulating cells in early-stage non-small cell lung cancer
Lavanya Ranganathan (German Cancer Research Centre) - Non-invasive genotyping and MRD monitoring by circulating tumour DNA in patients with solid tumours patients receiving targeted treatment within molecular tumour boards
Sophie Richardson (CRUK Manchester Institute) - Cell-free DNA methylome and fragmentome analysis for disease relapse monitoring in patients with Ewing Sarcoma
Closing Remarks and Prizes